Are there nonstop flights from Tucson (TUS) to Istanbul (IST)?

No. The fastest connection is via Denver, about 13h 48m of total flying time.

What is the fastest connection from Tucson (TUS) to Istanbul (IST)?

via Denver ≈ 13h 48m, via Chicago ≈ 14h 3m, via Dallas-Fort Worth ≈ 14h 23m (estimated flying time, excluding layovers).

from 27,500 ANA miles (economy, one way, based on the published award charts).

Tucson International Airport (TUS) to İstanbul Airport (IST)・10,868 km

No nonstop flights. The fastest connection is via Denver (DEN), about 13h 48m of flying time (layover not included).

With milesANA 27,500 miles+ (via DEN)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

8 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.