Are there nonstop flights from Tampa (TPA) to George Town (GCM)?

Yes. Cayman Airways fly this route. Flight time is about 1h 39m.

What is the fastest connection from Tampa (TPA) to George Town (GCM)?

via Miami ≈ 2h 15m, via Fort Lauderdale ≈ 2h 16m, via Nassau ≈ 2h 35m (estimated flying time, excluding layovers).

from 12,000 JAL miles (economy, one way, based on the published award charts).

Tampa International Airport (TPA) to Owen Roberts International Airport (GCM)・973 km

Nonstop flights available (1 airline). Flight time about 1h 39m. Nonstop return flights also operate.

With milesJAL 12,000 miles+ (via MIA)Economy, one way, estimate. Tap a connection for miles by cabin.

4 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.