Are there nonstop flights from Santiago (STI) to Frankfurt am Main (FRA)?

No. The fastest connection is via Madrid, about 10h 33m of total flying time.

What is the fastest connection from Santiago (STI) to Frankfurt am Main (FRA)?

via Madrid ≈ 10h 33m, via Boston ≈ 10h 56m, via New York ≈ 11h 5m (estimated flying time, excluding layovers).

from 35,000 ANA miles (economy, one way, based on the published award charts).

Cibao International Airport (STI) to Frankfurt Main Airport (FRA)・7,603 km

No nonstop flights. The fastest connection is via Madrid (MAD), about 10h 33m of flying time (layover not included).

With milesANA 35,000 miles+ (via EWR)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

7 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.