Are there nonstop flights from Sofia (SOF) to Porto (OPO)?

Yes. Bulgaria Air fly this route. Flight time is about 3h 37m.

What is the fastest connection from Sofia (SOF) to Porto (OPO)?

via Nice ≈ 4h 7m, via Pisa ≈ 4h 7m, via Bologna ≈ 4h 7m (estimated flying time, excluding layovers).

from 15,000 ANA miles (economy, one way, based on the published award charts).

Sofia Airport (SOF) to Francisco de Sá Carneiro Airport (OPO)・2,643 km

Nonstop flights available (1 airline). Flight time about 3h 37m. Nonstop return flights also operate.

With milesANA 15,000 miles+ (via ZRH)Economy, one way, estimate. Tap a connection for miles by cabin.

68 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.