Are there nonstop flights from Santa Ana (SNA) to Louisville (SDF)?

No. The fastest connection is via Phoenix, about 4h 29m of total flying time.

What is the fastest connection from Santa Ana (SNA) to Louisville (SDF)?

via Phoenix ≈ 4h 29m, via Las Vegas ≈ 4h 30m, via Denver ≈ 4h 32m (estimated flying time, excluding layovers).

from 15,000 ANA miles, from 15,000 JAL miles (economy, one way, based on the published award charts).

John Wayne Orange County International Airport (SNA) to Louisville Muhammad Ali International Airport (SDF)・2,921 km

No nonstop flights. The fastest connection is via Phoenix (PHX), about 4h 29m of flying time (layover not included).

With milesANA 15,000 miles+ (via DEN)JAL 15,000 miles+ (via DFW)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

17 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.