Are there nonstop flights from Santa Ana (SNA) to Manchester (MHT)?

No. The fastest connection is via Chicago, about 5h 52m of total flying time.

What is the fastest connection from Santa Ana (SNA) to Manchester (MHT)?

via Chicago ≈ 5h 52m, via Washington ≈ 6h 4m, via Nashville ≈ 6h 7m (estimated flying time, excluding layovers).

from 23,000 JAL miles (economy, one way, based on the published award charts).

John Wayne Orange County International Airport (SNA) to Manchester-Boston Regional Airport (MHT)・4,125 km

No nonstop flights. The fastest connection is via Chicago (ORD), about 5h 52m of flying time (layover not included).

With milesJAL 23,000 miles+ (via CLT)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

6 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.