Are there nonstop flights from Santa Ana (SNA) to Chicago (MDW)?

No. The fastest connection is via Colorado Springs, about 4h 16m of total flying time.

What is the fastest connection from Santa Ana (SNA) to Chicago (MDW)?

via Colorado Springs ≈ 4h 16m, via Des Moines ≈ 4h 17m, via Denver ≈ 4h 17m (estimated flying time, excluding layovers).

John Wayne Orange County International Airport (SNA) to Chicago Midway International Airport (MDW)・2,781 km

No nonstop flights. The fastest connection is via Colorado Springs (COS), about 4h 16m of flying time (layover not included).

None.

32 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.