Are there nonstop flights from San Juan (SJU) to Knoxville/Maryville (TYS)?

No. The fastest connection is via Charlotte, about 4h 8m of total flying time.

What is the fastest connection from San Juan (SJU) to Knoxville/Maryville (TYS)?

via Charlotte ≈ 4h 8m, via Jacksonville ≈ 4h 10m, via Atlanta ≈ 4h 13m (estimated flying time, excluding layovers).

from 15,000 JAL miles, from 30,000 ANA miles (economy, one way, based on the published award charts).

Luis Munoz Marin International Airport (SJU) to McGhee Tyson Airport (TYS)・2,618 km

No nonstop flights. The fastest connection is via Charlotte (CLT), about 4h 8m of flying time (layover not included).

With milesJAL 15,000 miles+ (via CLT)ANA 30,000 miles+ (via ORD)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

24 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.