Are there nonstop flights from San Francisco (SFO) to Guangzhou (CAN)?

Yes. China Southern Airlines fly this route. Flight time is about 13h 32m.

What is the fastest connection from San Francisco (SFO) to Guangzhou (CAN)?

via Shanghai ≈ 14h 2m, via Seoul ≈ 14h 3m, via Osaka ≈ 14h 7m (estimated flying time, excluding layovers).

from 22,500 ANA miles, from 45,000 JAL miles (economy, one way, based on the published award charts).

San Francisco International Airport (SFO) to Guangzhou Baiyun International Airport (CAN)・11,080 km

Nonstop flights available (1 airline). Flight time about 13h 32m. Nonstop return flights also operate.

With milesANA 22,500 miles+ (via HND)JAL 45,000 miles+ (via PVG)Economy, one way, estimate. Tap a connection for miles by cabin.

31 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.