Are there nonstop flights from Rio de Janeiro (SDU) to Santiago (SCL)?

No. The fastest connection is via São Paulo, about 4h 29m of total flying time.

What is the fastest connection from Rio de Janeiro (SDU) to Santiago (SCL)?

via São Paulo ≈ 4h 29m, via Belo Horizonte ≈ 5h 2m, via Brasília ≈ 5h 38m (estimated flying time, excluding layovers).

Santos Dumont Airport (SDU) to Comodoro Arturo Merino Benítez International Airport (SCL)・2,936 km

No nonstop flights. The fastest connection is via São Paulo (GRU), about 4h 29m of flying time (layover not included).

None.

4 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.