Are there nonstop flights from Santo Domingo (SDQ) to Charleston (CHS)?

No. The fastest connection is via Fort Lauderdale, about 3h 31m of total flying time.

What is the fastest connection from Santo Domingo (SDQ) to Charleston (CHS)?

via Fort Lauderdale ≈ 3h 31m, via Orlando ≈ 3h 31m, via Miami ≈ 3h 32m (estimated flying time, excluding layovers).

from 15,000 JAL miles, from 30,000 ANA miles (economy, one way, based on the published award charts).

Las Américas International Airport (SDQ) to Charleston International Airport (CHS)・1,912 km

No nonstop flights. The fastest connection is via Fort Lauderdale (FLL), about 3h 31m of flying time (layover not included).

With milesJAL 15,000 miles+ (via MIA)ANA 30,000 miles+ (via EWR)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

10 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.