Are there nonstop flights from Louisville (SDF) to Santo Domingo (SDQ)?

No. The fastest connection is via Atlanta, about 4h 15m of total flying time.

What is the fastest connection from Louisville (SDF) to Santo Domingo (SDQ)?

via Atlanta ≈ 4h 15m, via Orlando ≈ 4h 17m, via Fort Lauderdale ≈ 4h 19m (estimated flying time, excluding layovers).

from 15,000 JAL miles (economy, one way, based on the published award charts).

Louisville Muhammad Ali International Airport (SDF) to Las Américas International Airport (SDQ)・2,691 km

No nonstop flights. The fastest connection is via Atlanta (ATL), about 4h 15m of flying time (layover not included).

With milesJAL 15,000 miles+ (via MIA)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

8 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.