Are there nonstop flights from Louisville (SDF) to Fort Myers (RSW)?

Yes. Southwest Airlines, Breeze Airways fly this route. Flight time is about 2h 5m.

What is the fastest connection from Louisville (SDF) to Fort Myers (RSW)?

via Atlanta ≈ 2h 36m, via Orlando ≈ 2h 37m, via Nashville ≈ 2h 39m (estimated flying time, excluding layovers).

from 12,000 JAL miles (economy, one way, based on the published award charts).

Louisville Muhammad Ali International Airport (SDF) to Southwest Florida International Airport (RSW)・1,346 km

Nonstop flights available (2 airlines). Flight time about 2h 5m. Nonstop return flights also operate.

With milesJAL 12,000 miles+ (via CLT)Economy, one way, estimate. Tap a connection for miles by cabin.

22 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.