Are there nonstop flights from Louisville (SDF) to Madrid (MAD)?

No. The fastest connection is via Boston, about 9h of total flying time.

What is the fastest connection from Louisville (SDF) to Madrid (MAD)?

via Boston ≈ 9h, via Newark ≈ 9h 2m, via Philadelphia ≈ 9h 2m (estimated flying time, excluding layovers).

from 37,000 JAL miles (economy, one way, based on the published award charts).

Louisville Muhammad Ali International Airport (SDF) to Adolfo Suárez Madrid–Barajas Airport (MAD)・6,797 km

No nonstop flights. The fastest connection is via Boston (BOS), about 9h of flying time (layover not included).

With milesJAL 37,000 miles+ (via CLT)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

12 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.