Are there nonstop flights from San Pedro Sula (SAP) to Chicago (MDW)?

No. The fastest connection is via Atlanta, about 4h 32m of total flying time.

What is the fastest connection from San Pedro Sula (SAP) to Chicago (MDW)?

via Atlanta ≈ 4h 32m, via Orlando ≈ 4h 46m, via Houston ≈ 4h 50m (estimated flying time, excluding layovers).

Ramón Villeda Morales International Airport (SAP) to Chicago Midway International Airport (MDW)・2,928 km

No nonstop flights. The fastest connection is via Atlanta (ATL), about 4h 32m of flying time (layover not included).

None.

6 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.