Are there nonstop flights from San Diego (SAN) to St Louis (STL)?

Yes. Southwest Airlines fly this route. Flight time is about 3h 27m.

What is the fastest connection from San Diego (SAN) to St Louis (STL)?

via Phoenix ≈ 3h 58m, via Kansas City ≈ 3h 58m, via Denver ≈ 4h 4m (estimated flying time, excluding layovers).

from 15,000 JAL miles, from 15,000 ANA miles (economy, one way, based on the published award charts).

San Diego International Airport (SAN) to St. Louis Lambert International Airport (STL)・2,501 km

Nonstop flights available (1 airline). Flight time about 3h 27m. Nonstop return flights also operate.

With milesJAL 15,000 miles+ (via PHX)ANA 15,000 miles+ (via DEN)Economy, one way, estimate. Tap a connection for miles by cabin.

43 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.