Are there nonstop flights from San Diego (SAN) to Fort Myers (RSW)?

No. The fastest connection is via Austin, about 5h 5m of total flying time.

What is the fastest connection from San Diego (SAN) to Fort Myers (RSW)?

via Austin ≈ 5h 5m, via Houston ≈ 5h 6m, via Houston ≈ 5h 6m (estimated flying time, excluding layovers).

from 15,000 ANA miles, from 23,000 JAL miles (economy, one way, based on the published award charts).

San Diego International Airport (SAN) to Southwest Florida International Airport (RSW)・3,477 km

No nonstop flights. The fastest connection is via Austin (AUS), about 5h 5m of flying time (layover not included).

With milesANA 15,000 miles+ (via IAH)JAL 23,000 miles+ (via PHX)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

39 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.