Are there nonstop flights from San Diego (SAN) to Key West (EYW)?

No. The fastest connection is via Houston, about 5h 12m of total flying time.

What is the fastest connection from San Diego (SAN) to Key West (EYW)?

via Houston ≈ 5h 12m, via Dallas-Fort Worth ≈ 5h 17m, via Tampa ≈ 5h 24m (estimated flying time, excluding layovers).

from 15,000 ANA miles, from 23,000 JAL miles (economy, one way, based on the published award charts).

San Diego International Airport (SAN) to Key West International Airport (EYW)・3,557 km

No nonstop flights. The fastest connection is via Houston (IAH), about 5h 12m of flying time (layover not included).

With milesANA 15,000 miles+ (via ORD)JAL 23,000 miles+ (via DFW)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

17 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.