Are there nonstop flights from Rochester (ROC) to Key West (EYW)?

No. The fastest connection is via Raleigh/Durham, about 3h 28m of total flying time.

What is the fastest connection from Rochester (ROC) to Key West (EYW)?

via Raleigh/Durham ≈ 3h 28m, via Orlando ≈ 3h 29m, via Charlotte ≈ 3h 29m (estimated flying time, excluding layovers).

from 15,000 JAL miles, from 15,000 ANA miles (economy, one way, based on the published award charts).

Frederick Douglass Greater Rochester International Airport (ROC) to Key West International Airport (EYW)・2,098 km

No nonstop flights. The fastest connection is via Raleigh/Durham (RDU), about 3h 28m of flying time (layover not included).

With milesJAL 15,000 miles+ (via CLT)ANA 15,000 miles+ (via ORD)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

13 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.