Are there nonstop flights from Reno (RNO) to Knoxville/Maryville (TYS)?

No. The fastest connection is via Denver, about 4h 43m of total flying time.

What is the fastest connection from Reno (RNO) to Knoxville/Maryville (TYS)?

via Denver ≈ 4h 43m, via Nashville ≈ 4h 43m, via Las Vegas ≈ 4h 56m (estimated flying time, excluding layovers).

from 15,000 ANA miles, from 23,000 JAL miles (economy, one way, based on the published award charts).

Reno Tahoe International Airport (RNO) to McGhee Tyson Airport (TYS)・3,155 km

No nonstop flights. The fastest connection is via Denver (DEN), about 4h 43m of flying time (layover not included).

With milesANA 15,000 miles+ (via DEN)JAL 23,000 miles+ (via DFW)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

12 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.