Are there nonstop flights from Orenburg (REN) to Moscow (DME)?

No. The fastest connection is via Kazan, about 2h 32m of total flying time.

What is the fastest connection from Orenburg (REN) to Moscow (DME)?

via Kazan ≈ 2h 32m, via Yekaterinburg ≈ 3h 26m, via St. Petersburg ≈ 3h 54m (estimated flying time, excluding layovers).

Orenburg Central Airport (REN) to Domodedovo International Airport (DME)・1,222 km

No nonstop flights. The fastest connection is via Kazan (KZN), about 2h 32m of flying time (layover not included).

None.

6 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.