Are there nonstop flights from Raleigh/Durham (RDU) to Istanbul (IST)?

No. The fastest connection is via Dublin, about 11h 14m of total flying time.

What is the fastest connection from Raleigh/Durham (RDU) to Istanbul (IST)?

via Dublin ≈ 11h 14m, via Boston ≈ 11h 14m, via London ≈ 11h 15m (estimated flying time, excluding layovers).

from 27,500 ANA miles, from 37,000 JAL miles (economy, one way, based on the published award charts).

Raleigh-Durham International Airport (RDU) to İstanbul Airport (IST)・8,703 km

No nonstop flights. The fastest connection is via Dublin (DUB), about 11h 14m of flying time (layover not included).

With milesANA 27,500 miles+ (via FRA)JAL 37,000 miles+ (via CDG)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

24 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.