Are there nonstop flights from Portland (PWM) to Santa Ana (SNA)?

No. The fastest connection is via Chicago, about 5h 58m of total flying time.

What is the fastest connection from Portland (PWM) to Santa Ana (SNA)?

via Chicago ≈ 5h 58m, via Denver ≈ 5h 58m, via Detroit ≈ 5h 58m (estimated flying time, excluding layovers).

from 15,000 ANA miles, from 23,000 JAL miles (economy, one way, based on the published award charts).

Portland International Jetport (PWM) to John Wayne Orange County International Airport (SNA)・4,214 km

No nonstop flights. The fastest connection is via Chicago (ORD), about 5h 58m of flying time (layover not included).

With milesANA 15,000 miles+ (via ORD)JAL 23,000 miles+ (via DFW)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

17 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.