Are there nonstop flights from Punta Cana (PUJ) to Santiago (SCL)?

Yes. LATAM Airlines Chile, Arajet fly this route. Flight time is about 7h 18m.

What is the fastest connection from Punta Cana (PUJ) to Santiago (SCL)?

via Mendoza ≈ 7h 57m, via Bogota ≈ 7h 58m, via Lima ≈ 8h 3m (estimated flying time, excluding layovers).

from 17,500 ANA miles, from 37,000 JAL miles (economy, one way, based on the published award charts).

Punta Cana International Airport (PUJ) to Comodoro Arturo Merino Benítez International Airport (SCL)・5,783 km

Nonstop flights available (2 airlines). Flight time about 7h 18m. Nonstop return flights also operate.

With milesANA 17,500 miles+ (via BOG)JAL 37,000 miles+ (via MIA)Economy, one way, estimate. Tap a connection for miles by cabin.

21 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.