Are there nonstop flights from Panama City (PTY) to Greenville/Greer/Spartanburg (GSP)?

No. The fastest connection is via Orlando, about 4h 24m of total flying time.

What is the fastest connection from Panama City (PTY) to Greenville/Greer/Spartanburg (GSP)?

via Orlando ≈ 4h 24m, via Miami ≈ 4h 24m, via Tampa ≈ 4h 24m (estimated flying time, excluding layovers).

from 30,000 ANA miles (economy, one way, based on the published award charts).

Tocumen International Airport (PTY) to Greenville-Spartanburg International Airport (GSP)・2,886 km

No nonstop flights. The fastest connection is via Orlando (MCO), about 4h 24m of flying time (layover not included).

With milesANA 30,000 miles+ (via IAH)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

10 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.