Are there nonstop flights from Prague (PRG) to Santander (SDR)?

No. The fastest connection is via Paris, about 2h 56m of total flying time.

What is the fastest connection from Prague (PRG) to Santander (SDR)?

via Paris ≈ 2h 56m, via Milan ≈ 2h 58m, via Charleroi ≈ 3h (estimated flying time, excluding layovers).

from 15,000 JAL miles (economy, one way, based on the published award charts).

Václav Havel Airport Prague (PRG) to Seve Ballesteros-Santander Airport (SDR)・1,559 km

No nonstop flights. The fastest connection is via Paris (ORY), about 2h 56m of flying time (layover not included).

With milesJAL 15,000 miles+ (via MAD)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

23 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.