Are there nonstop flights from Prague (PRG) to Palermo (PMO)?

Yes. Ryanair, Wizz Air fly this route. Flight time is about 2h 4m.

What is the fastest connection from Prague (PRG) to Palermo (PMO)?

via Ronchi dei Legionari/Trieste ≈ 2h 34m, via Naples ≈ 2h 34m, via Rimini ≈ 2h 35m (estimated flying time, excluding layovers).

from 15,000 ANA miles, from 15,000 JAL miles (economy, one way, based on the published award charts).

Václav Havel Airport Prague (PRG) to Falcone–Borsellino Airport (PMO)・1,329 km

Nonstop flights available (2 airlines). Flight time about 2h 4m. Nonstop return flights also operate.

With milesANA 15,000 miles+ (via MUC)JAL 15,000 miles+ (via CDG)Economy, one way, estimate. Tap a connection for miles by cabin.

65 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.