Are there nonstop flights from Prague (PRG) to Košice (KSC)?

Yes. Ryanair fly this route. Flight time is about 1h 7m.

What is the fastest connection from Prague (PRG) to Košice (KSC)?

via Vienna ≈ 1h 45m, via Warsaw ≈ 2h 5m, via Zadar ≈ 2h 36m (estimated flying time, excluding layovers).

from 15,000 ANA miles (economy, one way, based on the published award charts).

Václav Havel Airport Prague (PRG) to Košice International Airport (KSC)・530 km

Nonstop flights available (1 airline). Flight time about 1h 7m. Nonstop return flights also operate.

With milesANA 15,000 miles+ (via VIE)Economy, one way, estimate. Tap a connection for miles by cabin.

4 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.