Are there nonstop flights from Prague (PRG) to São Paulo (GRU)?

No. The fastest connection is via Zurich, about 12h 54m of total flying time.

What is the fastest connection from Prague (PRG) to São Paulo (GRU)?

via Zurich ≈ 12h 54m, via Madrid ≈ 12h 54m, via Munich ≈ 12h 55m (estimated flying time, excluding layovers).

from 35,000 ANA miles, from 45,000 JAL miles (economy, one way, based on the published award charts).

Václav Havel Airport Prague (PRG) to São Paulo/Guarulhos–Governor André Franco Montoro International Airport (GRU)・10,118 km

No nonstop flights. The fastest connection is via Zurich (ZRH), about 12h 54m of flying time (layover not included).

With milesANA 35,000 miles+ (via ZRH)JAL 45,000 miles+ (via MAD)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

18 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.