Are there nonstop flights from Prague (PRG) to Charlotte (CLT)?

No. The fastest connection is via New York, about 9h 43m of total flying time.

What is the fastest connection from Prague (PRG) to Charlotte (CLT)?

via New York ≈ 9h 43m, via Philadelphia ≈ 9h 44m, via Dublin ≈ 9h 45m (estimated flying time, excluding layovers).

from 27,500 ANA miles, from 37,000 JAL miles (economy, one way, based on the published award charts).

Václav Havel Airport Prague (PRG) to Charlotte Douglas International Airport (CLT)・7,422 km

No nonstop flights. The fastest connection is via New York (JFK), about 9h 43m of flying time (layover not included).

With milesANA 27,500 miles+ (via MUC)JAL 37,000 miles+ (via PHL)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

11 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.