Are there nonstop flights from Paphos (PFO) to Lyon (LYS)?

Yes. Transavia France fly this route. Flight time is about 3h 34m.

What is the fastest connection from Paphos (PFO) to Lyon (LYS)?

via Rhodes ≈ 4h 5m, via Mykonos ≈ 4h 5m, via Athens ≈ 4h 6m (estimated flying time, excluding layovers).

from 15,000 ANA miles, from 23,000 JAL miles (economy, one way, based on the published award charts).

Paphos International Airport (PFO) to Lyon Saint-Exupéry Airport (LYS)・2,610 km

Nonstop flights available (1 airline). Flight time about 3h 34m. Nonstop return flights also operate.

With milesANA 15,000 miles+ (via ATH)JAL 23,000 miles+ (via AMM)Economy, one way, estimate. Tap a connection for miles by cabin.

30 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.