Are there nonstop flights from Portland (PDX) to Myrtle Beach (MYR)?

No. The fastest connection is via St Louis, about 5h 37m of total flying time.

What is the fastest connection from Portland (PDX) to Myrtle Beach (MYR)?

via St Louis ≈ 5h 37m, via Charlotte ≈ 5h 37m, via Kansas City ≈ 5h 37m (estimated flying time, excluding layovers).

from 15,000 ANA miles, from 23,000 JAL miles (economy, one way, based on the published award charts).

Portland International Airport (PDX) to Myrtle Beach International Airport (MYR)・3,912 km

No nonstop flights. The fastest connection is via St Louis (STL), about 5h 37m of flying time (layover not included).

With milesANA 15,000 miles+ (via DEN)JAL 23,000 miles+ (via CLT)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

25 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.