Are there nonstop flights from Portland (PDX) to Luton (LTN)?

No. The fastest connection is via Reykjavík, about 10h 14m of total flying time.

What is the fastest connection from Portland (PDX) to Luton (LTN)?

via Reykjavík ≈ 10h 14m, via Amsterdam ≈ 10h 52m (estimated flying time, excluding layovers).

Portland International Airport (PDX) to London Luton Airport (LTN)・7,855 km

No nonstop flights. The fastest connection is via Reykjavík (KEF), about 10h 14m of flying time (layover not included).

None.

2 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.