Are there nonstop flights from Portland (PDX) to Lexington (LEX)?

No. The fastest connection is via Chicago, about 4h 54m of total flying time.

What is the fastest connection from Portland (PDX) to Lexington (LEX)?

via Chicago ≈ 4h 54m, via Denver ≈ 4h 55m, via Minneapolis ≈ 4h 56m (estimated flying time, excluding layovers).

from 23,000 JAL miles (economy, one way, based on the published award charts).

Portland International Airport (PDX) to Blue Grass Airport (LEX)・3,226 km

No nonstop flights. The fastest connection is via Chicago (ORD), about 4h 54m of flying time (layover not included).

With milesJAL 23,000 miles+ (via DFW)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

12 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.