Are there nonstop flights from Chicago (ORD) to Prague (PRG)?

No. The fastest connection is via Edinburgh, about 9h 35m of total flying time.

What is the fastest connection from Chicago (ORD) to Prague (PRG)?

via Edinburgh ≈ 9h 35m, via Amsterdam ≈ 9h 37m, via Dublin ≈ 9h 39m (estimated flying time, excluding layovers).

from 27,500 ANA miles, from 37,000 JAL miles (economy, one way, based on the published award charts).

Chicago O'Hare International Airport (ORD) to Václav Havel Airport Prague (PRG)・7,298 km

No nonstop flights. The fastest connection is via Edinburgh (EDI), about 9h 35m of flying time (layover not included).

With milesANA 27,500 miles+ (via BRU)JAL 37,000 miles+ (via LHR)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

30 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.