Are there nonstop flights from Chicago (ORD) to Niš (INI)?

No. The fastest connection is via Belgrade, about 10h 41m of total flying time.

What is the fastest connection from Chicago (ORD) to Niš (INI)?

via Belgrade ≈ 10h 41m, via Vienna ≈ 10h 41m, via Zurich ≈ 10h 43m (estimated flying time, excluding layovers).

from 27,500 ANA miles (economy, one way, based on the published award charts).

Chicago O'Hare International Airport (ORD) to Niš Constantine the Great Airport (INI)・8,225 km

No nonstop flights. The fastest connection is via Belgrade (BEG), about 10h 41m of flying time (layover not included).

With milesANA 27,500 miles+ (via ZRH)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

5 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.