Are there nonstop flights from Porto (OPO) to Chalons en Champagne (XCR)?

Yes. Ryanair fly this route. Flight time is about 2h 3m.

Porto → Chalons en Champagne

Francisco de Sá Carneiro Airport (OPO) to Chalons Vatry airport (XCR)・1,311 km

Nonstop flights available (1 airline). Flight time about 2h 3m. Nonstop return flights also operate.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.