Are there nonstop flights from Porto (OPO) to Charlotte (CLT)?

No. The fastest connection is via New York, about 8h 17m of total flying time.

What is the fastest connection from Porto (OPO) to Charlotte (CLT)?

via New York ≈ 8h 17m, via Newark ≈ 8h 18m, via Boston ≈ 8h 19m (estimated flying time, excluding layovers).

from 27,500 ANA miles, from 40,000 JAL miles (economy, one way, based on the published award charts).

Francisco de Sá Carneiro Airport (OPO) to Charlotte Douglas International Airport (CLT)・6,164 km

No nonstop flights. The fastest connection is via New York (JFK), about 8h 17m of flying time (layover not included).

With milesANA 27,500 miles+ (via EWR)JAL 40,000 miles+ (via MAD)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

12 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.