Are there nonstop flights from Odesa (ODS) to Prague (PRG)?

Yes. SkyUp fly this route. Flight time is about 2h.

What is the fastest connection from Odesa (ODS) to Prague (PRG)?

via Vienna ≈ 2h 36m, via Warsaw ≈ 2h 44m, via Kyiv ≈ 2h 54m (estimated flying time, excluding layovers).

from 15,000 ANA miles (economy, one way, based on the published award charts).

Odesa International Airport (ODS) to Václav Havel Airport Prague (PRG)・1,279 km

Nonstop flights available (1 airline). Flight time about 2h. Nonstop return flights also operate.

With milesANA 15,000 miles+ (via VIE)Economy, one way, estimate. Tap a connection for miles by cabin.

12 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.