Are there nonstop flights from Milan (MXP) to San Diego (SAN)?

No. The fastest connection is via London, about 12h 28m of total flying time.

What is the fastest connection from Milan (MXP) to San Diego (SAN)?

via London ≈ 12h 28m, via Amsterdam ≈ 12h 32m, via Chicago ≈ 12h 47m (estimated flying time, excluding layovers).

from 27,500 ANA miles, from 40,000 JAL miles (economy, one way, based on the published award charts).

Milan Malpensa International Airport (MXP) to San Diego International Airport (SAN)・9,743 km

No nonstop flights. The fastest connection is via London (LHR), about 12h 28m of flying time (layover not included).

With milesANA 27,500 miles+ (via ORD)JAL 40,000 miles+ (via JFK)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

11 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.