Are there nonstop flights from Milan (MXP) to Johannesburg (JNB)?

No. The fastest connection is via Algiers, about 11h 4m of total flying time.

What is the fastest connection from Milan (MXP) to Johannesburg (JNB)?

via Algiers ≈ 11h 4m, via Zurich ≈ 11h 8m, via Munich ≈ 11h 23m (estimated flying time, excluding layovers).

from 30,000 ANA miles, from 37,000 JAL miles (economy, one way, based on the published award charts).

Milan Malpensa International Airport (MXP) to O.R. Tambo International Airport (JNB)・8,221 km

No nonstop flights. The fastest connection is via Algiers (ALG), about 11h 4m of flying time (layover not included).

With milesANA 30,000 miles+ (via ZRH)JAL 37,000 miles+ (via CDG)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

19 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.