Are there nonstop flights from Milan (MXP) to Charlotte (CLT)?

No. The fastest connection is via New York, about 9h 34m of total flying time.

What is the fastest connection from Milan (MXP) to Charlotte (CLT)?

via New York ≈ 9h 34m, via Philadelphia ≈ 9h 34m, via Newark ≈ 9h 34m (estimated flying time, excluding layovers).

from 27,500 ANA miles, from 37,000 JAL miles (economy, one way, based on the published award charts).

Milan Malpensa International Airport (MXP) to Charlotte Douglas International Airport (CLT)・7,278 km

No nonstop flights. The fastest connection is via New York (JFK), about 9h 34m of flying time (layover not included).

With milesANA 27,500 miles+ (via EWR)JAL 37,000 miles+ (via JFK)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

19 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.