Are there nonstop flights from Mexicali (MXL) to Puerto Vallarta (PVR)?

Yes. Volaris fly this route. Flight time is about 2h 27m.

What is the fastest connection from Mexicali (MXL) to Puerto Vallarta (PVR)?

via Guadalajara ≈ 3h 20m, via Silao ≈ 3h 41m, via Monterrey ≈ 3h 52m (estimated flying time, excluding layovers).

General Rodolfo Sánchez Taboada International Airport (MXL) to Puerto Vallarta International Airport (PVR)・1,657 km

Nonstop flights available (1 airline). Flight time about 2h 27m. Nonstop return flights also operate.

4 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.