Are there nonstop flights from New Orleans (MSY) to San Diego (SAN)?

Yes. Southwest Airlines fly this route. Flight time is about 3h 31m.

What is the fastest connection from New Orleans (MSY) to San Diego (SAN)?

via Phoenix ≈ 4h 2m, via Austin ≈ 4h 2m, via Houston ≈ 4h 3m (estimated flying time, excluding layovers).

from 15,000 JAL miles, from 15,000 ANA miles (economy, one way, based on the published award charts).

Louis Armstrong New Orleans International Airport (MSY) to San Diego International Airport (SAN)・2,568 km

Nonstop flights available (1 airline). Flight time about 3h 31m. Nonstop return flights also operate.

With milesJAL 15,000 miles+ (via PHX)ANA 15,000 miles+ (via IAH)Economy, one way, estimate. Tap a connection for miles by cabin.

37 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.