Are there nonstop flights from Minneapolis (MSP) to Santa Ana (SNA)?

Yes. Delta Air Lines fly this route. Flight time is about 3h 23m.

What is the fastest connection from Minneapolis (MSP) to Santa Ana (SNA)?

via Denver ≈ 3h 53m, via Las Vegas ≈ 3h 53m, via Colorado Springs ≈ 3h 54m (estimated flying time, excluding layovers).

from 15,000 ANA miles, from 15,000 JAL miles (economy, one way, based on the published award charts).

Minneapolis–Saint Paul International Airport / Wold–Chamberlain Field (MSP) to John Wayne Orange County International Airport (SNA)・2,446 km

Nonstop flights available (1 airline). Flight time about 3h 23m. Nonstop return flights also operate.

With milesANA 15,000 miles+ (via DEN)JAL 15,000 miles+ (via PHX)Economy, one way, estimate. Tap a connection for miles by cabin.

37 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.