Are there nonstop flights from Minneapolis (MSP) to Panama City (PTY)?

No. The fastest connection is via George Town, about 5h 57m of total flying time.

What is the fastest connection from Minneapolis (MSP) to Panama City (PTY)?

via George Town ≈ 5h 57m, via Tampa ≈ 5h 59m, via Atlanta ≈ 5h 59m (estimated flying time, excluding layovers).

from 23,000 JAL miles, from 30,000 ANA miles (economy, one way, based on the published award charts).

Minneapolis–Saint Paul International Airport / Wold–Chamberlain Field (MSP) to Tocumen International Airport (PTY)・4,198 km

No nonstop flights. The fastest connection is via George Town (GCM), about 5h 57m of flying time (layover not included).

With milesJAL 23,000 miles+ (via MIA)ANA 30,000 miles+ (via ORD)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

33 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.