Are there nonstop flights from Minneapolis (MSP) to Sioux Falls (FSD)?

Yes. Delta Air Lines, Delta Connection fly this route. Flight time is about 52m.

Minneapolis → Sioux Falls

Minneapolis–Saint Paul International Airport / Wold–Chamberlain Field (MSP) to Sioux Falls Regional Airport (FSD)・315 km

Nonstop flights available (2 airlines). Flight time about 52m. Nonstop return flights also operate.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.