Are there nonstop flights from Minneapolis (MSP) to Cape Town (CPT)?

No. The fastest connection is via Newark, about 17h 43m of total flying time.

What is the fastest connection from Minneapolis (MSP) to Cape Town (CPT)?

via Newark ≈ 17h 43m, via Washington ≈ 17h 44m, via Atlanta ≈ 18h 7m (estimated flying time, excluding layovers).

from 35,000 ANA miles, from 50,000 JAL miles (economy, one way, based on the published award charts).

Minneapolis–Saint Paul International Airport / Wold–Chamberlain Field (MSP) to Cape Town International Airport (CPT)・14,210 km

No nonstop flights. The fastest connection is via Newark (EWR), about 17h 43m of flying time (layover not included).

With milesANA 35,000 miles+ (via EWR)JAL 50,000 miles+ (via CDG)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

7 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.