Are there nonstop flights from Marseille (MRS) to Prague (PRG)?

Yes. Ryanair fly this route. Flight time is about 1h 41m.

What is the fastest connection from Marseille (MRS) to Prague (PRG)?

via Munich ≈ 2h 12m, via Milan ≈ 2h 12m, via Zurich ≈ 2h 12m (estimated flying time, excluding layovers).

from 12,000 JAL miles, from 15,000 ANA miles (economy, one way, based on the published award charts).

Marseille Provence Airport (MRS) to Václav Havel Airport Prague (PRG)・1,010 km

Nonstop flights available (1 airline). Flight time about 1h 41m. Nonstop return flights also operate.

With milesJAL 12,000 miles+ (via CDG)ANA 15,000 miles+ (via MUC)Economy, one way, estimate. Tap a connection for miles by cabin.

47 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.