Are there nonstop flights from Valletta (MLA) to Bucharest (OTP)?

Yes. Ryanair, Wizz Air fly this route. Flight time is about 2h 7m.

What is the fastest connection from Valletta (MLA) to Bucharest (OTP)?

via Sofia ≈ 2h 37m, via Tirana ≈ 2h 38m, via Catania ≈ 2h 39m (estimated flying time, excluding layovers).

from 15,000 ANA miles (economy, one way, based on the published award charts).

Malta International Airport (MLA) to Bucharest Henri Coandă International Airport (OTP)・1,381 km

Nonstop flights available (2 airlines). Flight time about 2h 7m. Nonstop return flights also operate.

With milesANA 15,000 miles+ (via ATH)Economy, one way, estimate. Tap a connection for miles by cabin.

40 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.